GLP-1 Weight Loss · United States

GLP-1 Medications in United States:
Complete 2025 Guide

Everything you need to know about semaglutide, tirzepatide, Ozempic, Wegovy, and Mounjaro — including cost, eligibility, and how to get a prescription online.

Check My Eligibility →Ozempic vs Wegovy

⚕️ Educational content only. Not medical advice. Consult a licensed provider.

What Is a GLP-1 Medication?

GLP-1 (glucagon-like peptide-1) receptor agonists are a class of injectable or oral medications that mimic a naturally occurring gut hormone. Originally developed to treat type 2 diabetes, they have revolutionized weight management after clinical trials demonstrated unprecedented weight loss results.

These medications work by signalling the brain that you're full (reducing appetite), slowing how fast food leaves your stomach (reducing caloric intake), and improving insulin sensitivity. The result is sustainable, medically supervised weight loss without the need for surgery.

Key fact:Participants in the STEP 1 trial lost an average of 14.9% of body weight on semaglutide 2.4 mg over 68 weeks — more than any previous non-surgical weight loss intervention.
Available Medications

GLP-1 Medications Available in United States

Compare the main options prescribed by licensed telehealth providers.

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Semaglutide

Ozempic / Wegovy
TypeGLP-1 agonist
Avg. weight loss~15%
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Tirzepatide

Mounjaro / Zepbound
TypeGLP-1 + GIP dual agonist
Avg. weight loss~20–22%
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Liraglutide

Saxenda
TypeGLP-1 agonist
Avg. weight loss~8–10%
Compare Semaglutide vs Tirzepatide →
Process

How to Get a GLP-1 Prescription Online in United States

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Step 01

Complete Online Intake

Fill out a 5-minute health questionnaire covering your BMI, medical history, and weight loss goals.

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Step 02

Physician Review

A licensed Canadian physician reviews your information and determines if GLP-1 therapy is appropriate for you.

Step 03

Prescription Issued

If approved, your prescription is sent to a compounding or retail pharmacy. Most medications ship within 3–5 days.

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Step 04

Track Your Progress

Use GLP Metrics dashboard to log your doses, track weight loss, and monitor your symptom forecast week by week.

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Eligibility Criteria in United States

In Canada, GLP-1 medications are typically approved for adults who meet one of the following criteria:

BMI ≥ 30 kg/m²
Adults with obesity qualify for weight management indications regardless of other conditions.
BMI ≥ 27 kg/m² + Weight-Related Condition
Overweight adults with type 2 diabetes, hypertension, dyslipidemia, or obstructive sleep apnea may qualify.
Type 2 Diabetes (Ozempic/Rybelsus)
Ozempic is Health Canada-approved specifically for blood sugar control in adults with type 2 diabetes, regardless of BMI.

Cost of GLP-1 Medications in United States

Prices vary depending on whether you use insurance, a retail pharmacy, or a compounding pharmacy through a telehealth provider.

MedicationRetail (no insurance)Telehealth Cash-PayWith Insurance
Ozempic (semaglutide)$280–$420/mo$199–$299/moOften covered (T2D)
Wegovy (semaglutide 2.4mg)$400–$550/mo$249–$349/moLimited coverage
Mounjaro (tirzepatide)$430–$590/mo$299–$399/moLimited coverage
Saxenda (liraglutide)$320–$450/mo$199–$280/moVaries by plan

* Prices are estimates based on publicly available telehealth provider pricing as of 2025. Actual costs may vary. Always verify with your provider.

Use Our Cost Calculator →

Frequently Asked Questions

What is a GLP-1 medication?

GLP-1 (glucagon-like peptide-1) receptor agonists are a class of medications that mimic a natural gut hormone to reduce appetite, slow gastric emptying, and lower blood sugar. They are FDA-approved for weight management and type 2 diabetes.

How do I get a GLP-1 prescription online in Canada?

Through a licensed telehealth provider, you complete an online intake form, a physician reviews your medical history, and if appropriate, issues a prescription. Most platforms ship directly to your door within 3–7 business days.

Is semaglutide or tirzepatide better for weight loss?

Clinical trials show tirzepatide achieves slightly higher average weight loss (~20–22% body weight) compared to semaglutide (~15%). However, individual results vary. The best medication depends on your health profile, which your provider will assess.

Are GLP-1 medications covered by insurance in Canada?

Coverage varies by province and plan. Ozempic is commonly covered for type 2 diabetes management. Wegovy (weight management indication) has more limited coverage. Many telehealth platforms offer transparent cash-pay pricing.

What are the most common side effects?

The most common side effects are nausea, vomiting, diarrhea, and constipation, particularly in the first 4–8 weeks as your dose is titrated up. These typically improve over time. Serious side effects are rare but include pancreatitis.

How long does it take to see results?

Most people experience appetite suppression within 1–2 weeks. Significant weight loss (5–10% of body weight) is typically observed by weeks 4–8, with maximum effect at 68 weeks according to STEP trial data.

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⚕️ This content is for informational purposes only and does not constitute medical advice. Always consult a licensed healthcare provider before starting any treatment.

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